Solo and Illya travel to the Caribbean to help Dr. Delgado, who is under a voodoo curse and in a zombielike trance thanks to the local dictator, El Supremo, and his chief of police, Captain Ramirez. The U.N.C.L.E. agents are assisted by Suzy, an American hairdresser whom El Supremo will not let leave the island. They eventually turn to voodoo queen Mama Lou to turn the tables on him.