Frank and Mike come face to face with a cold-blooded killer in solitary confinement at a high security prison who forces them both to reconsider where their lives are going. While watching Steve and Amy very closely as they deal with what looks like a desperate suicide attempt, Gabrielle begins to question where Steve's motives lie. Bart's frustrated by hospital delays as his young female patient suffers unbearable pain. With Frank away, Charlotte is left to run the ED and, in the process, learns that All Saints' new doctor isn't all he appears to be.